https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52610 Wed 21 Feb 2024 15:27:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9174 Wed 11 Apr 2018 16:17:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54484 Tue 27 Feb 2024 15:13:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37816 Tue 04 May 2021 12:32:05 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2488 Sat 24 Mar 2018 08:27:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1798 Sat 24 Mar 2018 08:27:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1793 Sat 24 Mar 2018 08:27:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19473 P-values alone, but researchers sometimes take account of external annotation information about the SNPs such as whether the SNP lies close to a good candidate gene. Using external information in this way is inherently subjective and is often not formalized, making the analysis difficult to reproduce. Building on previous work that has identified 14 important types of external information, we present an approximate Bayesian analysis that produces an estimate of the probability of association. The calculation combines four sources of information: the genome-wide data, SNP information derived from bioinformatics databases, empirical SNP weights, and the researchers’ subjective prior opinions. The calculation is fast enough that it can be applied to millions of SNPS and although it does rely on subjective judgments, those judgments are made explicit so that the final SNP selection can be reproduced. We show that the resulting probability of association is intuitively more appealing than the P-value because it is easier to interpret and it makes allowance for the power of the study. We illustrate the use of the probability of association for SNP prioritization by applying it to a meta-analysis of kidney function genome-wide association studies and demonstrate that SNP selection performs better using the probability of association compared with P-values alone.]]> Sat 24 Mar 2018 08:02:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30725 Rhinella marina) at the invasion front have been based on studies at a single site in the Northern Territory. To replicate the earlier work, we radio-tracked free-ranging toads in the Kimberley region of northwestern Australia (at the westward-spreading invasion front) and 500 km northeast, on the Adelaide River floodplain of the Northern Territory (where toads had already been present for 6 years). For comparison, we also radio-tracked native frogs (Litoria caerulea and L. splendida) at the same sites. Consistent with the earlier reports, invasion-front cane toads travelled further per day, were more highly directional, and re-used refuge sites less frequently, than did conspecifics from an already-colonized site. In contrast, native frogs showed similar movement patterns in the two study areas. Our results confirm previous reports, and suggest that accelerated dispersal may be a common feature of individuals at the vanguard of a biological invasion.]]> Sat 24 Mar 2018 07:32:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24685 10). In several studies, effect size estimates were substantially lower than in the original studies. To our knowledge, this is the first multi-study confirmatory replication of SBB correlations. With this study, we hope to encourage other researchers to undertake similar replication attempts.]]> Sat 24 Mar 2018 07:10:54 AEDT ]]>